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KMID : 0364820140500020087
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Korean Journal of Microbiology
2014 Volume.50 No. 2 p.87 ~ p.94
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Antimicrobial Mechanisms of Nitric Oxide and Strategies for Developing Nitric Oxide-based Antimicrobial Agents
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Choi Eun-Young
Noh Jin-Ki
Nurhasni Hasan
Yoo Jin-Wook
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Abstract
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Nitric oxide (NO), which has been recognized as an integral molecule in maintaining homeostasis, plays an important
role in host defense against microbes. NO has diverse antimicrobial mechanisms by directly and/or indirectly
interacting with microbes. Under the circumstance that there is an urgent need for a new class of antimicrobial agents
due to antibiotic resistance, much effort has been made to develop a NO-based antimicrobial agent. In order to make it
possible, strategies to store and release NO in a controlled manner are required because NO has a gaseous property
and a very short half-life. In this review, we described NO biochemistry and its mechanisms of antimicrobial activity.
In additions, we introduced various NO-releasing systems that improve NO’s antimicrobial activity.
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KEYWORD
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antimicrobial activity, nitric oxide (NO), NO-releasing systems
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